DrugindexOnline^{2nd edition}

Generic name: Piroxicam
Brand names: Feldene

Why is Piroxicam prescribed?

Feldene, a nonsteroidal anti-inflammatory drug, is used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis (the most common form of arthritis). It is prescribed both for sudden flare-ups and for long-term treatment.

Most important fact about Piroxicam

In a few patients on long-term therapy, Feldene can cause stomach ulcers and bleeding. Warning signs include severe abdominal or stomach cramps, pain or burning in the stomach, and black, tarry stools. Inform your doctor immediately if you develop any of these symptoms.

How should you take Piroxicam?

To avoid digestive side effects, take Feldene with food or an antacid, and with a full glass of water. Never take it on an empty stomach.

Take Piroxicam exactly as prescribed by your doctor. Avoid alcohol and aspirin while taking Piroxicam.

--If you miss a dose...

If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take two doses at the same time.

--Storage instructions...

Store at room temperature. Protect from light and heat.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Feldene.

• More common side effects may include:
  Abdominal pain or discomfort, anemia, constipation, diarrhea, dizziness, fluid retention, gas, general feeling of ill health, headache, heartburn, itching, kidney problems, loss of appetite, nausea, rash, ringing in ears, sleepiness, stomach ulcers or bleeding, stomach upset, vertigo, vomiting

This side effects list is not complete. If you have any questions about side effects you should consult your doctor. Report any new or continuing symptoms to your doctor right away.

Why should Piroxicam not be prescribed?

If you are sensitive to or have ever had an allergic reaction to Feldene, aspirin, or similar drugs, or if you have had asthma attacks caused by aspirin or other drugs of this type, you should not take Piroxicam. If you develop breathing difficulties or allergic symptoms after taking Feldene, seek emergency treatment immediately.

Special warnings about Piroxicam

The chances that Feldene will cause a stomach ulcer or bleeding are dramatically higher if you've had such problems previously. Severe stomach reactions are also more likely among older adults, those in poor health, smokers, heavy drinkers, and people taking steroids or blood thinners.

If you have heart disease, or high blood pressure, or other conditions that cause fluid retention, use Piroxicam with caution. Feldene can increase water retention.

Feldene has been known to damage the kidneys, and is not recommended for people with advanced kidney disease. Feldene can also cause liver damage. If you develop warning signs of liver dysfunction such as fatigue, itchiness, yellow skin or eyes, a flu-like feeling, and pain in the upper right abdomen, stop taking Feldene and see your doctor immediately.

Drugs such as Feldene may cause eye disturbances in some people. If you develop visual problems, notify your eye doctor.

Possible food and drug interactions when taking Piroxicam

If Feldene is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Feldene with the following:

Anticoagulants (blood thinners such as Coumadin)
Aspirin
Blood pressure medications known as ACE inhibitors, including Accupril, Altace, Mavik, Prinivil, and Zestril
Furosemide (Lasix)
Lithium (Lithobid, Lithonate)
Methotrexate (Rheumatrex)
Thiazide-type water pills such as HydroDIURIL

Special information if you are pregnant or breastfeeding

Feldene is not recommended for use in nursing mothers or pregnant women. If you are pregnant or plan to become pregnant, inform your doctor immediately.

Recommended dosage

ADULTS

Rheumatoid Arthritis and Osteoarthritis:

The usual dose is 20 milligrams a day in one dose. Your doctor may want you to divide this dose into smaller ones. You will not feel Feldene's full effects for 7 to 12 days, although some relief of symptoms will start to occur soon after you take the medication.

CHILDREN

The safety and effectiveness of Feldene have not been established in children.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

• Symptoms of Feldene overdose may include:
  Drowsiness, nausea, stomach pain, vomiting