DrugindexOnline^{2nd edition}

Generic name: Nadolol, Bendroflumethiazide
Brand names: Corzide

Why is Nadolol, Bendroflumethiazide prescribed?

Corzide is a combination drug used in the treatment of high blood pressure. It combines a beta blocker and a thiazide diuretic. Nadolol, the beta blocker, decreases the force and rate of heart contractions thereby reducing blood pressure. Bendroflumethiazide, the diuretic, helps your body produce and eliminate more urine, which also helps in lowering blood pressure.

Most important fact about Nadolol, Bendroflumethiazide

You must take Corzide regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Corzide; and you must continue taking it even if you are feeling well. Corzide does not cure high blood pressure; it merely keeps it under control.

How should you take Nadolol, Bendroflumethiazide?

Corzide may be taken with or without food. Take it exactly as prescribed, even if your symptoms have disappeared.

Try not to miss any doses. Corzide is taken once a day. If Nadolol, Bendroflumethiazide is not taken regularly, your condition may worsen.

--If you miss a dose...

Take it as soon as you remember. If it's within 8 hours of your next scheduled dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

--Storage instructions...

Store at room temperature, away from heat, in a tightly closed container.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Corzide.

• More common side effects may include:
  Asthma-like symptoms, changes in heart rhythm, cold hands and feet, dizziness, fatigue, low blood pressure, low potassium levels (symptoms include dry mouth, excessive thirst, weakness, drowsiness, restlessness, weak or irregular heartbeat, muscle pain or cramps, diminished urination, and digestive disturbances), slow heartbeat

Why should Nadolol, Bendroflumethiazide not be prescribed?

If you have bronchial asthma, slow heartbeat, certain heartbeat irregularities (heart block), inadequate blood supply to the circulatory system (cardiogenic shock), active congestive heart failure, inability to urinate, or if you are sensitive to or have ever had an allergic reaction to Corzide, its ingredients, or similar drugs, you should not take Nadolol, Bendroflumethiazide.

Special warnings about Nadolol, Bendroflumethiazide

If you have a history of congestive heart failure, your doctor will prescribe Corzide with caution.

Corzide should not be stopped suddenly. This can cause increased chest pain and even a heart attack. Dosage should be gradually reduced.

If you suffer from asthma, seasonal allergies, emphysema or other bronchial conditions, or kidney or liver disease, Nadolol, Bendroflumethiazide should be used with caution.

Ask your doctor if you should check your pulse while taking Corzide. It can cause your heartbeat to become too slow.

Corzide may mask the symptoms of low blood sugar or alter blood sugar levels. If you are diabetic, discuss this with your doctor. The drug can also cause thyroid problems, and may aggravate the rash and joint pain of lupus erythematosus.

This medication can cause you to become drowsy or less alert; therefore, activity that requires full mental alertness is not recommended until you know how you respond to Nadolol, Bendroflumethiazide.

Notify your doctor or dentist that you are taking Corzide if you have a medical emergency, or before you have surgery or dental treatment.

Possible food and drug interactions when taking Nadolol, Bendroflumethiazide

Corzide may intensify the effects of alcohol. Do not drink alcohol while taking Nadolol, Bendroflumethiazide.

If Corzide is taken with any other drug, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Corzide with the following:

Amphotericin B
Antidepressant drugs known as MAO inhibitors, such as Nardil and Parnate
Antidiabetic drugs, including insulin and oral drugs such as Micronase
Antigout drugs such as Benemid
Barbiturates such as phenobarbital
Blood thinners such as Coumadin
Calcium salt
Certain blood pressure drugs such as Diupres and Ser-Ap-Es
Cholestyramine (Questran)
Colestipol (Colestid)
Diazoxide (Proglycem)
Digitalis medications such as Lanoxin
Lithium (Lithonate)
Methenamine (Mandelamine)
Narcotics such as Percocet
Nonsteroidal anti-inflammatory drugs, such as Motrin, Naprosyn, and Nuprin
Other antihypertensives such as Vasotec
Steroid medications such as prednisone
Sulfinpyrazone (Anturane)

Special information if you are pregnant or breastfeeding

The effects of Corzide during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Corzide appears in breast milk and could affect a nursing infant. If Nadolol, Bendroflumethiazide is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Corzide is finished.

Recommended dosage

ADULTS

Dosages of Nadolol, Bendroflumethiazide are always tailored to the individual's needs.

The usual dose is 1 Corzide 40/5 milligram tablet per day or, if necessary, 1 Corzide 80/5 milligram tablet per day. If you have kidney problems, you'll probably need Corzide less frequently. If Nadolol, Bendroflumethiazide fails to bring your blood pressure under control, your doctor may gradually add another high blood pressure drug to your regimen.

CHILDREN

The safety and effectiveness of Corzide have not been established in children.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

• The symptoms of Corzide overdose may include:
  Abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, wheezing