DrugindexOnline^{2nd edition}

Generic Name: Botulinum Toxin Type B Injection (BOTT-you-lye-num)
Brand Name: Myobloc

Myobloc is used for:

Reducing the severity of abnormal head position and neck pain associated with neck problems. It may also be used for other conditions as determined by your doctor.

Myobloc is a neurotoxin. It works by blocking nerve impulses to the muscles, temporarily paralyzing the muscle.

Do NOT use Myobloc if:

• you are allergic to any ingredient in Myobloc
• you have an infection at the injection site

Contact your doctor or health care provider right away if any of these apply to you.

Before using Myobloc :

Some medical conditions may interact with Myobloc . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have nerve problems or disease (eg, amyotrophic lateral sclerosis, motor neuropathy), muscle problems or disease (eg, myasthenia gravis, Lambert-Eaton syndrome), heart problems, bleeding disorders, seizures, or severe weakness or wasting of the muscles at the injection site
• if you have inflammation, scarring, or other skin disorders at the injection site
• if you have used other botulinum toxin injections within the past 4 months

Some MEDICINES MAY INTERACT with Myobloc . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aminoglycosides (eg, gentamicin), anticholinesterase medicines (eg, neostigmine), lincosamides (eg, clindamycin), magnesium, neuromuscular blockers (eg, atracurium), polymyxin, or quinidine because the risk of toxic effects may be increased
• Anticoagulants (eg, warfarin) because the risk of bleeding at the injection site may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Myobloc may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Myobloc :

Use Myobloc as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Myobloc is administered as an injection at your doctor's office, hospital, or clinic.
• If you miss a dose of Myobloc , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Myobloc .

Important safety information:

• Myobloc may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Myobloc . Using Myobloc alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Do NOT exceed the recommended dose or use Myobloc for longer than prescribed without checking with your doctor.
• Myobloc contains albumin, which comes from human blood. There is an extremely rare risk of developing a viral disease or a central nervous system disease called Creutzfeldt-Jakob disease. No cases of viral diseases or Creutzfeldt-Jakob disease from albumin have been identified.
• To prevent injury, resume normal activities gradually after using Myobloc .
• Use Myobloc with extreme caution in CHILDREN. Safety and effectiveness have not been established for certain age groups.
• PREGNANCY and BREAST-FEEDING: It is unknown if Myobloc can cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Myobloc during pregnancy. It is unknown if Myobloc is excreted in breast milk. If you are or will be breast-feeding, check with your doctor to discuss the risks to your baby.

Possible side effects of Myobloc :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety, back pain; dizziness; drowsiness; dry eyes; dry mouth; flu-like symptoms; general weakness; headache; increased cough; nausea; neck pain; pain, redness, swelling, or tenderness at the injection site; runny nose; sensitivity to light; sweating; upset stomach; weakness of the muscles at or near the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding at the injection site; chest pain; difficulty swallowing; fever; irregular heartbeat; paralysis; pneumonia; seizures; shortness or breath; speech changes or problems; swelling of the hands or feet; vaginal irritation, odor, or discharge; vision changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include body weakness; paralysis.

Proper storage of Myobloc :

Myobloc is usually handled and stored by a health care provider. If you are using Myobloc at home, store Myobloc as directed by your pharmacist or health care provider. Keep Myobloc out of the reach of children and away from pets.

General information:

• If you have any questions about Myobloc , please talk with your doctor, pharmacist, or other health care provider.
• Myobloc is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Myobloc . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.