DrugindexOnline^{2nd edition}

Generic name: Isradipine
Brand names: DynaCirc CR, DynaCirc

Why is Isradipine prescribed?

DynaCirc, a type of medication called a calcium channel blocker, is prescribed for the treatment of high blood pressure. It is effective when used alone or with a thiazide-type diuretic to flush excess water from the body. Calcium channel blockers ease the workload of the heart by slowing down the passage of nerve impulses through the heart muscle, thereby slowing the beat. This improves blood flow through the heart and throughout the body and reduces blood pressure. A controlled-release version of Isradipine (DynaCirc CR) maintains lower blood pressure for 24 hours.

Most important fact about Isradipine

You must take DynaCirc regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of DynaCirc; and you must continue taking it even if you are feeling well. DynaCirc does not cure high blood pressure; it merely keeps it under control.

How should you take Isradipine?

Take Isradipine exactly as prescribed, even if your symptoms have disappeared. Try not to miss any doses. If DynaCirc is not taken regularly, your condition may worsen.

Swallow the capsule or tablet whole, without crushing or chewing it.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

--Storage instructions...

Store at room temperature, away from light, in a tightly closed container.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking DynaCirc.

• More common side effects may include:
  Dizziness, fluid retention, flushing, headache, pounding heartbeat

Why should Isradipine not be prescribed?

If you are sensitive to or have ever had an allergic reaction to DynaCirc or other calcium channel blockers such as Vascor and Procardia, you should not take Isradipine. Tell your doctor about any drug reactions you have experienced.

Special warnings about Isradipine

DynaCirc can cause your blood pressure to become too low. If you feel light-headed or faint, contact your doctor.

This medication should be carefully monitored if you have congestive heart failure, especially if you are also taking a beta-blocking medication such as Tenormin or Inderal.

Before having surgery, including dental surgery, tell the doctor that you are taking DynaCirc.

Possible food and drug interactions when taking Isradipine

If DynaCirc is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining DynaCirc with the following:

Beta-blocking blood pressure drugs such as Tenormin, Inderal, and Lopressor
Cimetidine (Tagamet)
Rifampin (Rifadin)

Special information if you are pregnant or breastfeeding

The effects of DynaCirc during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, consult your doctor immediately. DynaCirc may appear in breast milk and could affect a nursing infant. If Isradipine is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with DynaCirc is finished.

Recommended dosage

DYNACIRC

Your dosage will be adjusted to meet your individual needs.

The usual starting dose is 2.5 milligrams, 2 times a day, either alone or in combination with a thiazide diuretic drug. DynaCirc may lower blood pressure 2 to 3 hours after taking the first dose, but the full effect of the drug may not take place for 2 to 4 weeks.

After a 2- to 4-week trial, your doctor may increase the dosage by 5 milligrams per day every 2 to 4 weeks until a maximum dose of 20 milligrams per day is reached. Side effects may increase or become more common after a 10-milligram dose.

If you are an older adult or have kidney or liver disease, you should still begin treatment with a 2.5-milligram dose 2 times per day; however, your doctor will monitor you closely, since your condition may alter the effects of Isradipine.

DYNACIRC CR

The usual starting dose is 5 milligrams once a day, either alone or in combination with a thiazide diuretic. A starting dose of 5 milligrams once a day is also recommended for older adults and those with mild liver and kidney problems.

As with regular DynaCirc, the dosage may be increased to a maximum of 20 milligrams per day.

Overdosage

Although there is little information on DynaCirc, overdose has resulted in sluggishness, low blood pressure, and rapid heartbeat. The symptoms of overdose with other calcium channel blockers include drowsiness, severe low blood pressure, and rapid heartbeat.

If you suspect a DynaCirc overdose, seek medical attention immediately.