DrugindexOnline^{2nd edition}

Generic Name: Amantadine Capsules and Tablets (a-MAN-ta-deen)
Brand Name: Symmetrel

Amantadine is used for:

Preventing and treating certain types of flu. It is used to treat Parkinson disease and uncontrolled muscle movements caused by some medicines. It may also be used for other conditions as determined by your doctor.

Amantadine is an antiparkinson and antiviral agent. How Amantadine works against the flu is not known. It may block reproduction of the virus and decrease the ability of the virus to get into the cells. How Amantadine works against Parkinson disease is not known. It may increase a certain chemical in the brain.

Do NOT use Amantadine if:

• you are allergic to any ingredient in Amantadine
• you have uncontrolled narrow-angle glaucoma

Contact your doctor or health care provider right away if any of these apply to you.

Before using Amantadine :

Some medical conditions may interact with Amantadine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of heart problems (eg, congestive heart failure), swelling of your hands or feet, mental or mood problems, suicidal thoughts or actions, seizures, glaucoma, low blood pressure, dizziness when you stand or sit up, an eczema-like rash, or kidney or liver problems

Some MEDICINES MAY INTERACT with Amantadine . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Thioridazine because tremors may be worsened in Parkinson patients
• Anticholinergics (eg, scopolamine), hydrochlorothiazide, quinidine, quinine, stimulants (eg, caffeine, methylphenidate, pseudoephedrine), or triamterene because they may increase the risk of Amantadine 's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Amantadine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Amantadine :

Use Amantadine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Amantadine by mouth with or without food.
• If you are using Amantadine for the flu, take it for the full course of treatment. Keep using Amantadine even if you feel better in a few days. This will help clear up your infection completely.
• If you miss a dose of Amantadine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Amantadine .

Important safety information:

• Amantadine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Amantadine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Amantadine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Limit alcohol intake while you are taking Amantadine . Talk with you doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Amantadine ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Do not become overheated in hot weather or while you are being active; heatstroke may occur.
• Amantadine only works against certain types of the flu; it does not treat other viral infections (eg, the common cold).
• If you are taking Amantadine for the flu, be sure to use Amantadine for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The virus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• If you are taking Amantadine for Parkinson disease, increase physical activity slowly as your symptoms improve.
• Do not suddenly stop taking Amantadine without first checking with your doctor. Your dose may need to be lowered slowly to avoid side effects.
• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Amantadine . Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
• If your symptoms do not get better or if they get worse, check with your doctor.
• Use Amantadine with caution in the ELDERLY; they may be more sensitive to its effects.
• Amantadine should be used with extreme caution in CHILDREN younger than 1 year old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using this medicine while you are pregnant. Amantadine is found in breast milk. Do not breast-feed while taking Amantadine .

If you stop taking Amantadine suddenly, you may have WITHDRAWAL symptoms. These may include agitation, hallucinations, paranoia, anxiety, depression, confusion, or slurred speech.

Possible side effects of Amantadine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; blurred vision; constipation; diarrhea; dizziness; drowsiness; dry mouth or nose; headache; lightheadedness; nausea; strange dreams; tiredness; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; aggression; confusion; depression; fainting; fast or irregular heartbeat; fever; hallucinations; memory loss; mental or mood changes; muscle problems (eg, spasms, uncontrolled movements); paranoid thoughts; personality changes; seizures; severe or persistent drowsiness or trouble sleeping; shortness of breath; swelling of hands, legs, feet, or ankles; thoughts of suicide; trouble urinating; unusual anxiety or irritability; vision changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include aggression; chest pain; confusion; decreased urination; fast or irregular heartbeat; fever; hallucinations; loss of consciousness; mental or mood changes; seizures; severe drowsiness; severe or persistent headache or dizziness; tremor; trouble breathing; trouble walking. Overdose of Amantadine may cause death.

Proper storage of Amantadine :

Store Amantadine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Amantadine out of the reach of children and away from pets.

General information:

• If you have any questions about Amantadine , please talk with your doctor, pharmacist, or other health care provider.
• Amantadine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Amantadine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.