DrugindexOnline^{2nd edition}

Generic Name: rimantadine (ri MAN ta deen)
Brand Names: Flumadine

What is Flumadine (rimantadine)?

Rimantadine is an antiviral medication. It blocks the actions of viruses in your body.

Rimantadine is used to treat and prevent influenza A (a viral infection) in adults. It is also used to prevent influenza A in children.

There may be some flu seasons during which rimantadine is not recommended because certain flu strains may be resistant to this drug.

Rimantadine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Flumadine (rimantadine)?

Do not use this medicine if you are allergic to rimantadine or a similar medicine called amantadine (Symmetrel).

Before taking rimantadine, tell your doctor if you are allergic to any drugs, or if you have a seizure disorder, kidney disease, or liver disease.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Do not use FluMist nasal influenza "live vaccine" while you are being treated with rimantadine and for at least 48 hours after you stop taking rimantadine. The nasal vaccine may not be as effective if you receive it while you are taking rimantadine. Before taking rimantadine, tell your doctor if you have received a nasal flu vaccine within the past 14 days.

Avoid coming into close contact with someone who has a weak immune system, such as a person who is taking steroids, being treated for cancer, or has a bone marrow disorder or an illness such as HIV or AIDS. If you have a type of influenza that is resistant to rimantadine, your body may actually shed that virus and a person with a weak immune system could easily become ill from being near you.

What should I discuss with my healthcare provider before taking Flumadine (rimantadine)?

Do not use this medicine if you are allergic to rimantadine or a similar medicine called amantadine (Symmetrel).

Before taking rimantadine, tell your doctor if you are allergic to any drugs, or if you have:

• epilepsy or other seizure disorder;

• kidney disease; or
• liver disease.

If you have any of these conditions, you may not be able to use rimantadine, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether rimantadine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Flumadine (rimantadine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you are taking rimantadine to treat influenza A, take it within 48 hours of when you notice your first flu symptoms.

Take this medication with a full glass of water.

Measure the liquid form of rimantadine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Store rimantadine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a rimantadine overdose may include agitation, confusion, hallucinations, or uneven heart rate.

What should I avoid while taking Flumadine (rimantadine)?

Do not use FluMist nasal influenza "live vaccine" while you are being treated with rimantadine and for at least 48 hours after you stop taking rimantadine. The nasal vaccine may not be as effective if you receive it while you are taking rimantadine. Before taking rimantadine, tell your doctor if you have received a nasal flu vaccine within the past 14 days.

Avoid coming into close contact with someone who has a weak immune system, such as a person who is taking steroids, being treated for cancer, or has a bone marrow disorder or an illness such as HIV or AIDS. If you have a type of influenza that is resistant to rimantadine, your body may actually shed that virus and a person with a weak immune system could easily become ill from being near you.

Flumadine (rimantadine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using rimantadine and call your doctor at once if you have a seizure (black-out or convulsions).

Keep taking the medication and talk to your doctor if you have any of these less serious side effects:

• nausea, vomiting, diarrhea, loss of appetite, stomach pain;

• dry mouth;

• sleep problems (insomnia);

• dizziness;

• headache; or

• anxiety, trouble concentrating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Flumadine (rimantadine)?

Before taking rimantadine, tell your doctor if you are using any of the following drugs:

• cimetidine (Tagamet);

• aspirin or acetaminophen (Tylenol); or

• nasal flu vaccine (FluMist).

If you are using any of these drugs, you may not be able to use rimantadine, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect rimantadine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has more information about rimantadine written for health professionals that you may read.

What does my medication look like?

Rimantadine is available with a prescription under the brand name Flumadine. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Flumadine 100 mg--oval, orange, film-coated tablets

• Flumadine Syrup 50 mg per 5 mL (1 teaspoon)--purplish-red syrup with a raspberry flavor

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.03. Revision Date: 04/11/2007 4:11:47 PM.